Diastase (or alpha-amylase) is an enzyme substance involved in the breakdown of carbohydrates. Thanks to amylase, complex carbohydrate compounds of food are broken down into small carbohydrates (glucose). Diastase is produced by the pancreas – the so-called pancreatic diastasis, also the salivary glands, and other organs. Diastase enters the urine due to glomerular filtration.
To detect diseases of the pancreas, as well as other organs, determine the level of diastase (amylase) in the blood or urine. And extremely bad if this level is elevated.
Of all the enzymes inherent in urine, diastasis is the most important from the point of view of diagnosis. Urine for diastase is given to diagnose diseases affecting the pancreas, salivary glands, and to identify the causes of pain in the abdomen.
Diseases resulting from a large amount of amylase
Elevated levels of amylase can be a dangerous symptom of diseases such as acute (or chronic) pancreatitis (the so-called inflammation of the pancreas), renal failure, parotitis, peritonitis, cyst, cholecystitis, diabetes mellitus, etc. In such diseases, the level of amylase increases 10 times. and more.
The level of amylase may increase due to various injuries of the abdomen, as well as due to abortion. If the assay shows zero amylase values, this signals insufficient pancreatic function, which is a signal of acute (or chronic) hepatitis. During pregnancy with toxicosis, a decrease in the amount of amylase is also possible.
Analysis of diastase. Norm
To determine a substance such as urine diastase, daily urine analysis is taken. Doctors recommend collecting urine in such a way: remove the first morning portion, and, starting from the second, collect urine that is excreted during the day. In the diagnosis of amylase (urine diastase), the rate ranges from 16 to 64 U / h. According to the Volgemut diastasis method, the urine in a healthy person should not exceed 64 units. Therefore, with an increase in diastase in the urine, there is every reason to believe that the pancreas is most likely affected. Less commonly, urinary diastasis may be present in large quantities not because of a pancreas lesion, but as a result of other diseases, such as cholecystitis or peritonitis.
Very important is the analysis of blood and urine for diastase. The level of diastase rises first in the blood, and only then increases its content in the urine, so the study is important especially in the early stages of pancreatitis. In acute cases, the amount of amylase usually increases markedly in the first hours of the onset of the disease. Then the elevated level is maintained for three days. If the progression of the disease is protracted, then this level of diastase persists for several weeks. An increased amount of amylase in the urine does not always indicate the severity of the patient’s condition, since the level of amylase can be normal and even lowered with pancreatic necrosis. A rapid decrease in the amount of diastase can signal a progressive pathological process in the gland.
Urinary diastase may slightly increase with diseases such as gastritis, acute hepatitis, pleurisy, appendicitis. Much attention is paid to the diagnosis of pancreatitis, the amount of diastase in which varies from 128-256 units. In such cases, the disease can be diagnosed with great confidence.
Drugs that increase the amount of diastase in the urine (blood)
It is important to know that the amount of amylase in the urine may increase due to taking certain medications. First of all, the group of such drugs included:
– non-medical drugs (heroin, cocaine and